February 16, 2026 Epilepsy disease classification: a community effort to enhance the Mondo Disease Ontology Epilepsy is a diverse group of neurological disorders affecting over 50 million people worldwide.
February 6, 2026 Use of AI within COA linguistic validation and eCOA migration processes: analysis and good practice recommendations While there has been much discussion around the use of Artificial Intelligence (AI) for multilingual translations in other...
April 25, 2025 Is Tau Approaching a Tipping Point in Alzheimer’s Drug Development? Is tau the new amyloid? Leaders in the Alzheimer’s field have high conviction in tau — both as a target and surrogate ...
December 12, 2025 Emerging Therapies in Autosomal Dominant Polycystic Kidney Disease Autosomal dominant polycystic kidney disease (ADPKD) is the most...
December 3, 2025 Rare Disease COA Consortium Publication on Study Designs and Crafting Endpoints for Gene Therapy Development Programs in Rare Disease C-Path’s Rare Disease COA Consortium is delighted to share that “Study Designs and Crafting Endpoints...
July 14, 2025 Principles of good practice for concept definition in the context of translation and linguistic validation of clinical outcome assessments (COAs) Translation teams conducting translation and cultural adaptation find it paramount to properly describe concepts of items...
June 9, 2025 Delivering regulatory impact from consortium-based projects Multiple consortia have been established in the past two decades with the aim of tackling roadblocks in the development of...
May 13, 2025 Considerations and Approaches to Establishing Estimates of Meaningful Change for Digital Endpoints as Drug Development Tools This paper seeks to identify some of the complexities associated with determining meaningful change for endpoints derived from...
April 25, 2025 Developing digital health technologies for frontotemporal degeneration Frontotemporal degeneration (FTD) is a rare neurodegenerative disease in which patients can present with cognitive, behavioral...
April 3, 2025 Systematic review and consensus conceptual model of meaningful symptoms and functional impacts in early Parkinson’s Disease A comprehensive, patient-centered conceptual model of early Parkinson’s is lacking and is greatly...
