June 9, 2025 Delivering regulatory impact from consortium-based projects Multiple consortia have been established in the past two decades with the aim of tackling roadblocks in the development of...
May 13, 2025 Considerations and Approaches to Establishing Estimates of Meaningful Change for Digital Endpoints as Drug Development Tools This paper seeks to identify some of the complexities associated with determining meaningful change for endpoints derived from...
April 25, 2025 Developing digital health technologies for frontotemporal degeneration Frontotemporal degeneration (FTD) is a rare neurodegenerative disease in which patients can present with cognitive, behavioral...
April 3, 2025 Systematic review and consensus conceptual model of meaningful symptoms and functional impacts in early Parkinson’s Disease A comprehensive, patient-centered conceptual model of early Parkinson’s is lacking and is greatly needed.
March 24, 2025 A Tutorial and Use Case Example of the eXtreme Gradient Boosting (XGBoost) Artificial Intelligence Algorithm for Drug Development Applications Approaches to artificial intelligence and machine learning (AI/ML) continue to advance in the field of drug development.
March 21, 2025 Wrangling Real-World Data: Optimizing Clinical Research Through Factor Selection with LASSO Regression Data-driven approaches to clinical research are necessary for understanding and effectively treating infectious diseases.
March 13, 2025 Principles of good practice for translation of electronic clinical outcome assessments While many publications have outlined good practice recommendations for translation and electronic implementation of clinical...
January 14, 2025 Addressing the need for Standardization of Symptomatic Medication Documentation in Parkinson’s Disease Clinical Research: A Call to Action People with Parkinson's disease (PD) are prescribed a variety of medications to mitigate symptoms and improve their quality...
February 25, 2025 A Framework to Standardize Gait Study Protocols in Parkinson’s Disease Research over the past twenty years has shown that gait outcomes have a high sensitivity for diagnosing Parkinson's disease (PD)..
February 1, 2025 Understanding what aspects of Parkinson’s disease matter most to patients and families Understanding what matters to people with Parkinson’s and their family is essential to derive relevant clinical outcome measures
