The best kept secret
path forward
in drug development.

Critical Path Institute is a nonprofit that generates solutions to facilitate scientific and regulatory pathways that accelerate the development of therapies for people with unmet medical needs.

Our tools foster collaboration between scientific and regulatory bodies.

Alzheimer’s Pre-dementia Clinical Trial Enrichment Tool

A quantitative clinical trial enrichment tool to help optimize clinical trial design in the pre-dementia stages of Alzheimer’s disease.

A quantitative clinical trial enrichment tool to help optimize clinical trial design in the pre-dementia stages of Alzheimer’s disease.

Alzheimer´s Solid Badge

Alzheimer’s Disease Clinical Trial Simulation Tool

A clinical trial simulation tool to help optimize clinical trial design for mild and moderate AD.

A clinical trial simulation tool to help optimize clinical trial design for mild and moderate AD.

Alzheimer´s Solid Badge

DMD Clinical Trial Simulation (CTS) Tool

The Duchenne Muscular Dystrophy (DMD) CTS Tool optimizes clinical trial design of efficacy studies of potential therapies for DMD.

The Duchenne Muscular Dystrophy (DMD) CTS Tool optimizes clinical trial design of efficacy studies of potential therapies for DMD.

Neuromuscular disease

Early Motor Parkinson’s DAT Clinical Trial Enrichment Tool

A quantitative clinical trial enrichment tool to help optimize clinical trial design in the early-motor stages of Parkinson’s disease.

A quantitative clinical trial enrichment tool to help optimize clinical trial design in the early-motor stages of Parkinson’s disease.

Parkinson´s Solid Badge

Islet Antibody Clinical Trial Enrichment Tool

This quantitative clinical trial enrichment tool helps optimize clinical trial design for therapies to prevent or delay diagnosis of T1D, using islet AAs with other relevant clinical features.

This quantitative clinical trial enrichment tool helps optimize clinical trial design for therapies to prevent or delay diagnosis of T1D, using islet AAs with other relevant clinical features.

clinical trials

PRO Consortium Measures and Licensing

This platform delivers information regarding available measures covering different therapeutic areas.

This platform delivers information regarding available measures covering different therapeutic areas.

COAs Solid Badge

Rare Disease Clinical Outcome Assessment Resource

The Rare Disease COA Resource provides information on published COAs that have the potential to be used to support efficacy endpoints in treatment trials for rare diseases.

The Rare Disease COA Resource provides information on published COAs that have the potential to be used to support efficacy endpoints in treatment trials for rare diseases.

Data Sharing

Critical Path for Alzheimer’s Disease Database

The database contains, but is not limited to, demographic information, APOE4 genotype, concomitant medications, and cognitive scales (MMSE and ADAS-Cog).

The database contains, but is not limited to, demographic information, APOE4 genotype, concomitant medications, and cognitive scales (MMSE and ADAS-Cog).

Alzheimer´s Solid Badge

Duchenne Regulatory Science Consortium Database

Duchenne Muscular Dystrophy Data is fully de-identified and compliant to the terms and conditions specified by the data owners.

Duchenne Muscular Dystrophy Data is fully de-identified and compliant to the terms and conditions specified by the data owners.

Neuromuscular disease

Integrated Parkinson’s Database

CPP’s Integrated Parkinson’s Database is a comprehensive collection of observational and clinical studies related to Parkinson’s.

CPP’s Integrated Parkinson’s Database is a comprehensive collection of observational and clinical studies related to Parkinson’s.

Parkinson´s Solid Badge

The Multiple Sclerosis Outcome Assessments Consortium (MSOAC) Placebo Database

The MSOAC Database presently includes 2465 individual patient records from 9 clinical trials.

The MSOAC Database presently includes 2465 individual patient records from 9 clinical trials.

Multiple Sclerosis

Polycystic Kidney Disease Outcomes Consortium Database

The Polycystic Kidney Disease Outcomes Consortium database consists of de-identified data from three longitudinal observational patient registries.

The Polycystic Kidney Disease Outcomes Consortium database consists of de-identified data from three longitudinal observational patient registries.

PKD

The Rare Disease Cures Accelerator-Data and Analytics Platform (RDCA-DAP®)

RDCA-DAP® promotes the sharing of existing patient-level data and encourages the standardization of new data collection.

RDCA-DAP® promotes the sharing of existing patient-level data and encourages the standardization of new data collection.

Data Collab Solid Badge

TB Platform for the Aggregation of Preclinical Experiments Data (TB-APEX)

The TB-Platform was created for the aggregation of preclinical experiments’ data.

The TB-Platform was created for the aggregation of preclinical experiments’ data.

Tuberculosis Solid Badge

TB Platform for Aggregation of Clinical TB Studies (TB-PACTS)

This platform is designed to catalyze and accelerate TB research.

This platform is designed to catalyze and accelerate TB research.

Tuberculosis Solid Badge

TB Platform for the Project to Accelerate New Treatments for Tuberculosis (PAN-TB)

The PAN-TB data platform is designed to catalyze and accelerate TB research by curating and standardizing Pharmacokinetic and relapsing mouse model (RMM) study data and making this data publicly available to qualified researchers.

The PAN-TB data platform is designed to catalyze and accelerate TB research by curating and standardizing Pharmacokinetic and relapsing mouse model (RMM) study data and making this data publicly available to qualified researchers.

To make a difference for patients and their families.

Our programs align the
medical community around
common goals.

Core Competencies

Our areas of expertise are essential to the tools we create.

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Neuroscience

Rare and Orphan Diseases

Pediatrics

Innovation in Translational Science and Biomarkers

Clinical Outcome Assessment