Volumetric MRI-Based Biomarkers in Huntington’s Disease: An Evidentiary Review
C-Path’s Huntington’s Disease Regulatory Science Consortium (HD-RSC) has published a new paper on volumetric MRI-based biomarkers in HD. The manuscript summarizes published evidence of regional brain volume losses in HD, cross-sectional correlations between regional brain volumes and disease characteristics, longitudinal change characteristics of the volumetric measures, and their relationships with clinical change and disease progression. Read the full open-access article here.
Stay tuned for the companion manuscript that will be available online soon which highlights recommendations to optimize the use of vMRI in HD clinical trials.