Recommendations to Optimize the Use of Volumetric MRI in Huntington’s Disease in Clinical Trials

C-Path’s Huntington’s Disease Regulatory Science Consortium (HD-RSC) has published a new paper on volumetric MRI-based biomarkers in HD. The manuscript is a companion to a recent manuscript that summarized published evidence of regional brain volume losses in HD, cross-sectional correlations between regional brain volumes and disease characteristics, longitudinal change characteristics of the volumetric measures, and their relationships with clinical change and disease progression. This manuscript aims to provide direction toward a more standardized use of vMRI in HD clinical research.

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