C-Path’s Predictive Safety Testing team presented this workshop at the 27th National Institute of Health (NIH) Tissue Chip Consortium Joint Meeting. The Complex In Vitro Model Workshop was held on March 5-6, 2026 at the National Cancer Institute in Rockville, Md. Over the past 13 years, the NIH has brought together members of the NIH Tissue Chip Consortium, including funded academic investigators, members of the pharmaceutical industry, and government agencies to accelerate the use, adoption, and ultimately dissemination of tissue chip technology across the United States.
This year, NIH has partnered with C-Path’s Predictive Safety Testing Consortium, a recognized global leader in drug development, to put together a joint meeting at no registration cost focused on accelerating the employment of tissue chips within the drug development pipeline. Day 1 focused on Contexts of Use for Today and Tomorrow and Evidentiary Considerations for MPS, while Day 2 focused on Integration of In-Silico NAMs, including tissue chips.
| 27th NIH Tissue Chip Consortium Meeting + CIVM Qualification Framework Public Workshop: Day 1 March 5, 2026 | |||
| Topic | Summary | Speakers | Links |
| Welcome | Opening Remarks and Introductions |
Nicholas King &
Joni Rutter (NCATS Director) | Video Recording |
| TraCE-MPS-ISTAND and BoT Patch Program | The NIH Tissue Chip for Drug Screening Program | Passley Hargrove-Grimes (NIH/NCATS) |
Slides
Video Recording |
| A Translational Center for Microphysiological Systems-Based Drug Development Tools for Pregnancy and Women’s Health | Ivan Rusyn (Texas A&M University) |
Slides
Video Recording | |
| Liver Acinus Microphysiological System (LAMPS) for Determining Drug Candidate Dosing in Clinical Trials of Liver Disease | Mark Schurdak (U. Pittsburgh) | Slides Video Recording | |
| Updates on TraCe-bMPS LOIs for Juvenile Dermatomyositis and Neurotoxicity from T-cell Engaging Immunotherapies | James McGrath (U. Rochester) | Slides Video Recording | |
| Update on LOI for the Human Kidney Chip for Assessment of Relative Nephrotoxicity | Johnathan Himmelfarb (Icahn School of Medicine at Mount Sinai) | ||
| High-Throughput NMJ Assay for Botox Potency Screening | Nicholas Geisse (Curi Bio) | Slides Video Recording | |
| Human Neuromuscular Junction Platform to Evaluate Botulinum Toxin Potency | James Hickman (Hesperos) | Slides Video Recording | |
| Panel Discussion | Session Speakers + Nakissa Sadrieh (FDA/CDER) + Marc Ferrer (NIH/NCATS) | Video Recording | |
| Tissue Chips in Space 2.0 | Welcome to the New Tissue Chips in Space 2.0 Cohort | Dmitriy Krepkiy (NIH/NCATS) | Slides Video Recording |
| Introduction to the Tissue Chips in Space 2.0 Program on the International Space Station | Mike Roberts (ISS National Lab) | Slides Video Recording | |
| Assessing Effects of Microgravity on Cardiovascular Aging with AI and 3D Organoids | Joseph Wu (Stanford) | Slides Video Recording | |
| Brain-muscle microphysiological system enabled extracellular vesicle network for understanding aging in space | Mei He (U. Florida) | Video Recording | |
| Impact of Aging in Space on Neurodegenerative diseases | Krishna Bhat (U. Alabama at Birmingham) | ||
| Induced Pluripotent Stem Cell Derived Organ-Chips for In-Space Modeling of Human Physiology | Arun Sharma (Cedars-Sinai) | Video Recording | |
| An Organ-on-Chip Approach to Evaluation of Reproductive Health, Aging and Disease in Women | Dylan Gordon (CFD Research) | Slides Video Recording | |
| An Aging Alveolar Lung Model in Microgravity | Shrike Zhang (Harvard Medical School) | Slides Video Recording | |
| Lunch Break | |||
| Evidentiary Considerations | Industrializing Organ-on-a-Chip Technology: Considerations for designing High-Throughput | Kim Homan (Genentech, Virtual Presentation) | |
| Evolution of Organ-on-a-Chip Technology: A Developer’s Journey | Lorna Ewart (Emulate) | Slides Video Recording | |
| Translating NAM Innovation into Regulatory Practice: FDA Progress and Collaborative Opportunities | Ksenia Blinova (FDA/CDER) | Slides Video Recording | |
| Building Cross-Sector Consensus on the Credibility of Complex In Vitro Models | Courtney Sakolish (Texas A&M) | Slides Video Recording | |
| Break | |||
|
Breakout Session Recaps | Dose Translation Breakout Session Recap | Sri Kidambi/Deidre Dalmas | Slides Video Recording |
| Immune Component Breakout Session Recap | Rebecca Pompano | Slides Video Recording | |
| Disease Modeling Breakout Session Recap | Ramona Belfiore-Oshan/Tina Morrison | Slides Video Recording | |
| Closing | Day 1 Summary | Nicholas King (C-Path) | |
|
27th NIH Tissue Chip Consortium Meeting + CIVM Qualification Framework Public Workshop: Day 2
March 6, 2026 | |||
| Topic | Summary | Speakers | Links |
|
Keynotes | NAMs Regulatory Needs in Japan | Seiichi Ishida (NIHS) |
Slides
Video Recording |
| The National Center to Accelerate Cures: A Joint Initiative between Blackbird Laboratories and Critical Path Institute | Matt Tremblay (Blackbird Labs) |
Slides
Video Recording | |
| Integration of in silico NAMs | Disruptive Technologies: MPS & AI | Thomas Hartung (Johns Hopkins) |
Slides
Video Recording |
| Regulatory Considerations for Use of New Approach Methodologies (NAMs) for Cardiovascular Drug Products | Jordan Pomeroy (FDA/CDER, Virtual Presentation) | Slides Video Recording | |
| From Animal to Algorithm: in Silico NAMs at FDA/NCTR | Weida Tong (FDA/NCTR, Virtual Presentation) | Slides Video Recording | |
| Integration of AI with biology for drug safety prediction | Amir Bein (Quris AI) | ||
| Panel Discussion | Session Chairs + Matt Tremblay (Blackbird Labs) | Video Recording | |
| Break | |||
| Breakout Session Recaps | Summary of Breakout Sessions | Combinatorial NAM Breakout Session Recap |
Slides
Video Recording |
| Data Harmonization Breakout Session Recap | Mark Schurdak/Klaus Romero/Jack Collins |
Slides
Video Recording | |
| Model Scalability Breakout Session Recap | Madhu Nag/Julie Frearson |
Slides
Video Recording | |
| Public Workshop Closing | NIH Summary Perspective of the Workshop | Christine Happel (NIH/NCATS) | Video Recording |
| FDA Summary Perspective of the Workshop | Ksenia Blinova (FDA/CDER) | Video Recording | |
| C-Path Summary of Conference | Klaus Romero (C-Path) | Video Recording | |
