I-ACT Webinars and Publications
The Institute for Advanced Clinical Trials for Children (I-ACT) was a 501(c)(3) nonprofit organization. I-ACT was funded through grants and memberships by biopharmaceutical companies, and philanthropy. I-ACT was founded in 2017. It emerged from the vision of multistakeholder leaders in pediatric drug development assembled by the American Academy of Pediatrics. These stakeholders recognized that children needed better access to safe, effective pediatric drugs, biologics and medical devices. I-ACT was established to meet these needs by providing the resources necessary to conduct efficient and effective pediatric clinical trials. From 2017 until its close in 2025, I-ACT provided visionary resources for people taking place in these clinical trials. You can access the suite of webinars via C-Path’s YouTube page here, or read the publications below:
Publications
Noel GJ, Connor E. Commentary: “Emergency Use Authorization for Remdesivir: A Pediatric Perspective”. Pediatr Infect Dis J. 2020 Sep;39(9):e234. doi: 10.1097/INF.0000000000002799. PMID: 32639464.
Noel GJ, Connor E. Commentary: “Emergency Use Authorization for Remdesivir: A Pediatric Perspective”. Pediatr Infect Dis J. 2020 Sep;39(9):e234. doi: 10.1097/INF.0000000000002799. PMID: 32639464.
Noel GJ, Nelson RM, Bucci-Rechtweg C, Portman R, Miller T, Green DJ, Snyder D, Moreno C, Hovinga C, Connor E. Inclusion of Adolescents in Adult Clinical Trials: Report of the Institute for Advanced Clinical Trials for Children’s Pediatric Innovation Research Forum. Ther Innov Regul Sci. 2021 Jul;55(4):773-778.
https://link.springer.com/article/10.1007/s43441-021-00283-y
Why Pediatric Clinical Trials Need to Grow Up – Cindy Jackson
Totally Clinical: Trial Triumphs & Rad Trends – 2023
Sabah Attar, Angie Price, Breanne Stewart, Thierry Lacaze-Masmonteil, Fedele Bonifazi, Fondazione Mark Turner, Ricardo Fernande, Harmonizing quality improvement metrics across global trial networks to advance paediatric clinical trials delivery, Therapeutic Innovation & Regulatory Science
https://link.springer.com/article/10.1007/s43441-024-00663-0
Coppes, M.J. Harmonizing the methodology and metrics definitions across pediatric clinical trials networks, an important step towards better health outcomes in children. Pediatr Res
Significant delays exist in industry-sponsored pediatric clinical drug trial start-up and enrollment processes. Angie Price, Hannah Simmons, Emily Gehring, Lauren Davis, Gwyneth Fischer, Ann R. Klipsch, Erin Richmond, Janice E. Sullivan, Steven J. Steiner, Contemporary Clinical Trials
https://www.sciencedirect.com/science/article/abs/pii/S1551714424002842
Eva Degraeuwe, Collin Hovinga, De Maré, A., Ricardo Fernandes, Heaton, C., Nuytinck, Persijn, L., Raes, A., Vande Walle, J., & Mark Turner.(2024). Partnership of I-ACT for children (US) and European pediatric clinical trial networks to facilitate pediatric clinical trials. Frontiers in Pediatrics, 12, 1388170.
https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2024.1388170/full
Collaborators
- Advocate Children’s Hospital – Oak Lawn
- Advocate Children’s Hospital – Park Ridge
- Ann and Lurie Children’s Hospital
- Children’s Hospital of Orange County
- Children’s Hospital of Philadelphia
- Children’s Mercy Hospital
- Children’s National Hospital
- Cleveland Clinic Children’s
- Hennepin County Medical Center
- Johns Hopkins University-Baltimore
- Le Bonheur Children’s Hospital
- Lucile Packard Children’s Hospital
- Medstar Medical Center
- Nationwide Children’s Hospital
- Nemours Children’s Specialty Care, Delaware
- Nemours Children’s Specialty Care, Jacksonville FL
- Orlando Health-Arnold Palmer Children’s Hospital
- Prisma Health Children’s Hospital
- Rhode Island Hospital/Hasbro Children’s
- Riley Children’s Hospital
- Rutgers-Robert Wood Johnson Medical School
- Tufts-Baystate Children’s Hospital
- Texas Children’s
- University of Colorado
- University of Louisville-Norton Children’s Hospital
- University of New Mexico Health Sciences Center
- University of Texas Health Sciences
- University of Utah
- VCU Children’s Hospital
- West Virginia University Children’s Hospital
- Yale New Haven Hospital
