Part of the Rapid Drug Susceptibility Testing (RDST) working group of the CPTR Initiative, the Relational Sequencing TB Data Platform (ReSeqTB) collects global TB patient data currently dispersed among multiple private and public databases. Once gathered and standardized, this resource will be foundational for the work being driven by the RDST consortium working groups to help identify correlations between MTB mutations and clinically relevant resistance, aid in the development of new rapid drug susceptibility tests, facilitate international research and collaboration, and, one day, directly enable sequencing data interpretation for personalized patient care.
The goals of ReSeqTB are to provide:
- A comprehensive, curated, one-stop data source for clinically relevant, globally representative genotypic and phenotypic information, and associated metadata on M.tuberculosis polymorphisms
- A data source for polymorphisms found in M. tuberculosis, both those associated with known drug resistance as well as those not associated with known drug resistance
- An improved research resource to enable development of new diagnostic tests that can rapidly detect drug-specific resistance using M. tuberculosis genotypic markers
- A foundation for developing a curated reference resource for clinicians.