The Problem

More than 6 million Americans and 55 million persons worldwide are living with dementia. Alzheimer’s disease (AD) is the most common form of dementia and may contribute to 60–70% of cases. However, dementia describes only the end stage of Alzheimer’s disease (AD). New estimates indicate that 416 million persons worldwide are currently living with the AD disease across the disease continuum – a number driven by an estimated ~300 million individuals worldwide living with preclinical AD. As the U.S. population aged 65 and older continues to grow, so too will the number and proportion of Americans with AD or other dementias. Without meaningful and effective therapies, the number of people with confirmed Alzheimer’s disease dementia is projected to rise to nearly 13 million within the United Stated by 2050 and 153 million worldwide. This estimate does not include persons in the predementia stages of disease, which provides a window of opportunity for prevention.   

While two disease-modifying therapies (aducanumab and lecanemab) have received regulatory (FDA) approval over the last few years, there is still a critical need for continued development of novel therapeutic interventions to address the complete spectrum of people living with AD, considering the vast heterogeneity in the underlying biology and pathological progression of the disease. Challenges in clinical research and drug development include selecting the optimal patient population for evaluating novel mechanisms of action (patient stratification), ability to pick up the earliest signals of the disease (early stages of AD including pre-symptomatic), selection of the right endpoints and outcome assessments, molecular signatures of disease biology and pathology (biomarkers), treatment effect assessments, and correlations of the outcome assessments with clinical meaningfulness.  

The Solution

CPAD is a global, neutral convener, bringing together diverse stakeholders across industry, regulatory agencies, and academia within a pre-competitive forum under a data-driven, regulatory framework to accelerate therapeutic innovation in AD. 

Leveraging the intellectual brain power and wealth of scientific knowledge gained from patient-level data contributions within the CPAD consortium, we identify the most critical unmet needs in AD and use our core competencies in data management, aggregation, and analysis, to facilitate informed decision making in AD drug development.